Table 2 Risk of incident pancreatic cancer by family history of cancer

Family history	No. of cases	Person-years	HR for pancreatic cancer (95% CI)
Family history	No. of cases	Person-years	Age-adjusted	Multivariable-adjusted^a
Breast cancer
Absent	195	435,771	1 (referent)	1 (referent)
Present	46	76,038	1.37 (0.99–1.90)	1.40 (1.01–1.94)
Colorectal cancer
Absent	372	1,021,094	1 (referent)	1 (referent)
Present	80	152,732	1.20 (0.94–1.54)	1.21 (0.95–1.55)
Pancreatic cancer
Absent	55	145,931	1 (referent)	1 (referent)
Present	8	7529	2.49 (1.17–5.33)	2.79 (1.28–6.07)
Melanoma
Absent	283	646,495	1 (referent)	1 (referent)
Present	12	30,435	0.91 (0.51–1.62)	0.90 (0.50–1.60)
Prostate cancer
Absent	285	665,289	1 (referent)	1 (referent)
Present	55	114,591	1.10 (0.82–1.47)	1.10 (0.82–1.48)
Lung cancer
Absent	197	457,620	1 (referent)	1 (referent)
Present	29	55,818	1.12 (0.75–1.68)	1.15 (0.77–1.72)

CI Confidence interval, HR hazard ratio, MET metabolic equivalent of task
^aThe Cox proportional hazards regression models were adjusted for age (continuous), race (white, black, other, or unknown), calendar year of questionnaire cycle (continuous), smoking in pack-years (never, 0.1–4.9, 5–19.9, 20–39.9, or ≥40), history of diabetes (yes/no), body mass index (<25, 25–29.9, 30–34.9, or ≥35 kg/m²), physical activity (MET-hours/week in quintiles), alcohol intake (0, 0.1–4.9, 5–14.9, 15–29.9, or ≥30 g/day), and regular multivitamin use (yes/no)

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