Table 3 Risk of incident pancreatic cancer by family history of cancer with adjustment for Ashkenazi Jewish ancestry

Family history	No. of cases	Person-years	HR for pancreatic cancer (95% CI)
Family history	No. of cases	Person-years	Age-adjusted	Multivariable-adjusted^a
Breast cancer
Absent	167	331,775	1 (referent)	1 (referent)
Present	43	57,475	1.49 (1.06–2.10)	1.50 (1.07–2.12)
Colorectal cancer
Absent	207	417,949	1 (referent)	1 (referent)
Present	52	72,484	1.28 (0.94–1.74)	1.27 (0.93–1.73)
Pancreatic cancer
Absent	52	109,930	1 (referent)	1 (referent)
Present	8	5681	2.76 (1.29–5.93)	3.05 (1.39–6.69)
Melanoma
Absent	189	354,438	1 (referent)	1 (referent)
Present	9	17,796	0.97 (0.49–1.90)	0.96 (0.49–1.90)
Prostate cancer
Absent	201	381,247	1 (referent)	1 (referent)
Present	37	68,343	1.01 (0.71–1.44)	1.03 (0.72–1.47)
Lung cancer
Absent	138	267,933	1 (referent)	1 (referent)
Present	20	32,726	1.11 (0.69–1.80)	1.14 (0.70–1.85)

CI Confidence interval, HR hazard ratio, MET metabolic equivalent of task
^aThe Cox proportional hazards regression models were adjusted for age (continuous), race (white, black, other, or unknown), calendar year of questionnaire cycle (continuous), smoking in pack-years (never, 0.1–4.9, 5–19.9, 20–39.9, or ≥40), history of diabetes (yes/no), body mass index (<25, 25–29.9, 30–34.9, or ≥35 kg/m²), physical activity (MET-hours/week in quintiles), alcohol intake (0, 0.1–4.9, 5–14.9, 15–29.9, or ≥30 g/day), regular multivitamin use (yes/no), and AJ ancestry (yes/no)

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