Table 3 Post-operative histology in procedures performed for malignancy
All procedures performed for cancer (n = 2607) | Mastectomy only (n = 1564) | Implant (n = 707) | Pedicled flap (n = 105) | Free-flap (n = 231) | P-value | |
|---|---|---|---|---|---|---|
Patients having NAC with a complete pathological response (n = 408) | 135 (32.0) | 66 (29.1) | 52 (41.9) | 9 (42.9) | 8 (22.2) | 0.031 |
Invasive status | <0.001 | |||||
Pre-invasive disease | 388 (14.8) | 141 (9.0) | 163 (23.1) | 26 (24.8) | 58 (25.1) | |
Invasive disease | 2186 (83.9) | 1413 (90.4) | 533 (75.4) | 77 (73.3) | 163 (70.6) | |
Not reported | 33 (1.3) | 10 (0.36) | 11 (1.6) | 2 (1.9) | 10 (4.3) | |
Focality | 0.001 | |||||
Unifocal disease | 1740 (66.7) | 1091 (69.8) | 446 (63.1) | 72 (68.6) | 131 (56.7) | |
Multifocal disease | 836 (32.1) | 455 (29.1) | 251 (35.5) | 33 (31.4) | 97 (42.0) | |
Not reported | 31 (1.2) | 18 (1.2) | 10 (1.4) | 0 (0.0) | 3 (1.3) | |
Invasive disease (n = 2186) grade | 0.045 | |||||
Grade 1 | 179 (8.2) | 98 (6.9) | 58 (10.9) | 7 (9.1) | 16 (9.8) | |
Grade 2 | 1187 (54.3) | 759 (53.7) | 285 (53.5) | 47 (61.0) | 96 (58.9) | |
Grade 3 | 800 (36.6) | 543 (38.4) | 186 (24.1) | 21 (27.3) | 50 (30.7) | |
Not reported | 20 (0.9) | 13 (0.9) | 4 (0.8) | 2 (2.6) | 1 (0.6) | |
Histological type | 0.489 | |||||
Ductal | 1540 (70.5) | 986 (69.8) | 382 (71.7) | 55 (71.4) | 117 (71.8) | |
Lobular | 373 (17.1) | 246 (17.4) | 89 (16.7) | 10 (13.0) | 28 (17.2) | |
Mixed | 121 (5.5) | 80 (5.7) | 26 (4.9) | 4 (5.2) | 11 (6.8) | |
Other | 141 (6.5) | 95 (6.7) | 34 (6.4) | 6 (7.8) | 6 (3.7) | |
Not reported | 11 (0.5) | 6 (0.4) | 2 (0.4) | 2 (2.6) | 1 (0.6) | |
Tumour stage | <0.001 | |||||
Tis | 388 (14.9) | 141 (9.0) | 163 (23.1) | 26 (24.8) | 58 (25.1) | |
T1a (<0.5 cm) | 187 (7.2) | 88 (5.6) | 71 (10.0) | 9 (8.6) | 19 (8.2) | |
T1b (0.5–1 cm) | 179 (6.9) | 89 (5.7) | 63 (8.9) | 13 (12.4) | 14 (6.1) | |
T1c (1–2 cm) | 578 (22.2) | 359 (23.0) | 156 (22.1) | 17 (16.2) | 46 (19.9) | |
T2 (2–5 cm) | 948 (36.4) | 672 (43.0) | 185 (26.2) | 28 (26.7) | 63 (27.3) | |
T3 (>5 cm) | 272 (10.4) | 190 (12.2) | 55 (7.8) | 9 (8.6) | 18 (7.8) | |
Not reported | 55 (2.1) | 25 (1.6) | 14 (2.0) | 3 (2.9) | 13 (5.6) | |
Lymphovascular invasion | 637 (29.1) | 435 (30.8) | 134 (25.1) | 22 (28.6) | 46 (28.2) | 0.141 |
ER | <0.001 | |||||
Positive | 1738 (79.5) | 1106 (78.3) | 445 (83.5) | 56 (72.7) | 131 (80.4) | |
Negative | 433 (19.8) | 298 (21.1) | 86 (16.1) | 18 (23.4) | 31 (19.0) | |
Unknown | 15 (0.7) | 4 (0.3) | 2 (0.4) | 3 (3.9) | 1 (0.6) | |
HER-2 | 0.871 | |||||
Positive | 422 (19.3) | 273 (19.3) | 109 (20.5) | 12 (15.6) | 28 (17.2) | |
Negative | 1686 (77.1) | 1087 (76.9) | 408 (76.6) | 61 (79.2) | 130 (79.8) | |
Unknown | 78 (3.6) | 53 (3.8) | 16 (3.0) | 4 (5.2) | 5 (3.1) | |
Nodal status | <0.001 | |||||
N0 | 1663 (63.8) | 905 (57.9) | 523 (74.0) | 71 (67.6) | 164 (71.0) | |
N1 | 944 (36.2) | 659 (42.1) | 184 (26.0) | 34 (32.4) | 67 (29.0) | |
Pre-invasive disease (n = 388) | 0.396 | |||||
Low grade | 27 (7.0) | 7 (5.0) | 12 (7.4) | 1 (3.8) | 7 (12.1) | |
Intermediate grade | 90 (23.2) | 38 (27.0) | 38 (23.3) | 5 (19.2) | 9 (15.5) | |
High grade | 269 (69.3) | 95 (67.4) | 112 (68.7) | 20 (76.9) | 42 (72.4) | |
Not reported | 2 (0.5) | 1 (0.7) | 1 (0.6) | 0 (0.0) | 0 (0.0) | |
