Table 5 Cox univariable and multivariable survival analyses for time to adjuvant treatment
Univariable | Multivariable (N = 1018) | ||||
|---|---|---|---|---|---|
N (%) | Hazard ratioa (95% confidence intervals) | P-value | Hazard ratioa (95% confidence intervals) | P-value | |
Procedure type | 1131 | ||||
Mastectomy only | 738 (65.3%) | Reference | Reference | ||
Implant-based | 260 (23.0%) | 1.08 (0.90, 1.29) | 0.42 | 1.07 (0.88, 1.31) | 0.496 |
Pedicled flap | 48 (4.2%) | 0.74 (0.49, 1.11) | 0.149 | 0.72 (0.47, 1.08) | 0.114 |
Free-flap | 85 (7.5%) | 0.84 (0.73, 0.97) | 0.019 | 0.84 (0.71, 0.99) | 0.036 |
Post-operative complications | 1131 | ||||
None | 685 (60.6%) | Reference | Reference | ||
Minor complications | 360 (31.8%) | 0.80 (0.70, 0.92) | 0.002 | 0.85 (0.73, 1.00) | 0.046 |
Major complications | 86 (7.6%) | 0.68 (0.54, 0.86) | 0.001 | 0.63 (0.49, 0.82) | 0.001 |
Chemotherapy as first adjuvant treatment | 1131 | 1.79 (1.55, 2.06) | <0.001 | 2.42 (2.09, 2.81) | <0.001 |
Age | 1128 | 1.00 (0.99, 1.00) | 0.206 | 1.01 (1.00, 1.01) | 0.058 |
BMI | 1078 | ||||
Underweight | 28 (2.6%) | 1.03 (0.67, 1.59) | 0.878 | 0.98 (0.66, 1.47) | 0.933 |
Normal weight | 387 (35.9%) | Reference | Reference | ||
Overweight | 354 (32.8%) | 0.99 (0.85, 1.15) | 0.867 | 1.00 (0.85, 1.17) | 0.953 |
Obese | 188 (17.4%) | 0.74 (0.65, 0.84) | <0.001 | 0.76 (0.64, 0.89) | 0.001 |
Severely obese | 121 (11.2%) | 0.72 (0.61, 0.85) | <0.001 | 0.81 (0.67, 0.97) | 0.023 |
Comorbidities | |||||
Ischaemic heart disease | 1128 | ||||
No | 1079 (95.7%) | Reference | Reference | ||
Yes | 49 (4.3%) | 0.69 (0.53, 0.89) | 0.005 | 0.82 (0.57, 1.18) | 0.279 |
Diabetes | 1103 | ||||
No | 1002 (90.8%) | Reference | Reference | ||
Yes | 101 (9.2%) | 0.78 (0.68, 0.90) | 0.001 | 0.94 (0.79, 1.13) | 0.53 |
Other comorbidity | 1123 | ||||
No | 638 (56.8%) | Reference | Reference | ||
Yes | 485 (43.2%) | 0.88 (0.75, 1.03) | 0.109 | 0.86 (0.70, 1.07) | 0.17 |
Smoking status | 1115 | ||||
Non-smoker | 805 (72.2%) | Reference | Reference | ||
Ex-smoker | 170 (15.3%) | 1.11 (0.92, 1.34) | 0.275 | 1.18 (0.96, 1.44) | 0.111 |
Current smoker | 140 (12.6%) | 0.95 (0.81, 1.11) | 0.496 | 0.88 (0.72, 1.07) | 0.186 |
Neoadjuvant chemotherapy | 1121 | ||||
No | 829 (74.0%) | Reference | Reference | ||
Yes | 292 (26.1%) | 0.99 (0.87, 1.11) | 0.808 | 1.71 (1.44, 2.03) | <0.001 |
ASA grade | 1126 | ||||
1 | 357 (31.7%) | Reference | Reference | ||
2 | 654 (58.1%) | 0.90 (0.78, 1.04) | 0.154 | 1.09 (0.89, 1.33) | 0.389 |
3 | 113 (10.0%) | 0.85 (0.67, 1.08) | 0.183 | 1.13 (0.78, 1.62) | 0.524 |
4 | 2 (0.2%) | 0.73 (0.61, 0.87) | 0.001 | 1.37 (0.87, 2.14) | 0.176 |
Bilateral surgery (vs none) | 1131 | 0.92 (0.77, 1.10) | 0.374 | 0.93 (0.75, 1.17) | 0.546 |
