Table 2 Odds ratio of colorectal adenoma according to total physical activity during adolescence by location of adenoma. Nurses’ Health Study II, 1997–2011

From: Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses’ Health Study II

 

Total physical activity during adolescence (in MET-h/week)

 

<21

21 to < 36

36 to < 48

48 to < 72

72+

Per 21 MET-h/week

P trend

All adenomas

  N Cases

503

579

416

466

409

  

  Age-adjusteda

1

1.01 (0.90–1.15)

1.06 (0.93–1.22)

0.90 (0.79–1.03)

0.88 (0.77–1.01)

0.96 (0.93–0.99)

0.01

  Multivariableb

1

1.02 (0.90–1.16)

1.07 (0.94–1.23)

0.91 (0.80–1.04)

0.89 (0.77–1.02)

0.96 (0.93–0.99)

0.02

  Multivariableb plus adult physical activity

1

1.02 (0.90–1.16)

1.08 (0.94–1.23)

0.92 (0.80–1.05)

0.90 (0.78–1.03)

0.96 (0.93–1.00)

0.03

Location of adenoma

 Proximal adenoma

   N Cases

252

290

205

227

197

  

   Age-adjusteda

1

1.02 (0.85–1.21)

1.05 (0.87–1.27)

0.88 (0.73–1.06)

0.85 (0.70–1.03)

0.95 (0.91–0.99)

0.03

   Multivariableb

1

1.02 (0.85–1.21)

1.06 (0.87–1.28)

0.89 (0.73–1.07)

0.86 (0.70–1.04)

0.95 (0.91–1.00)

0.04

   Multivariableb plus adult physical activity

1

1.02 (0.86–1.22)

1.06 (0.88–1.29)

0.90 (0.74–1.08)

0.87 (0.72–1.07)

0.96 (0.91–1.00)

0.07

 Distal adenoma

   N Cases

219

255

174

193

188

  

   Age-adjusteda

1

1.03 (0.85–1.23)

1.02 (0.83–1.25)

0.86 (0.71–1.05)

0.93 (0.76–1.14)

0.97 (0.92–1.02)

0.21

   Multivariableb

1

1.04 (0.87–1.26)

1.04 (0.85–1.28)

0.88 (0.72–1.07)

0.94 (0.76–1.15)

0.97 (0.92–1.02)

0.22

   Multivariableb plus adult physical activity

1

1.04 (0.86–1.26)

1.04 (0.85–1.28)

0.88 (0.72–1.08)

0.94 (0.77–1.16)

0.97 (0.92–1.02)

0.26

 Rectal adenoma

   N cases

84

86

73

81

74

  

   Age-adjusteda

1

0.90 (0.66–1.21)

1.11 (0.80–1.52)

0.93 (0.68–1.27)

0.94 (0.69–1.30)

0.99 (0.92–1.07)

0.80

   Multivariableb

1

0.91 (0.67–1.24)

1.13 (0.82–1.55)

0.94 (0.69–1.29)

0.94 (0.68–1.30)

0.99 (0.91–1.07)

0.76

   Multivariableb plus adult physical activity

1

0.92 (0.68–1.25)

1.15 (0.84–1.58)

0.96 (0.70–1.32)

0.97 (0.69–1.35)

0.99 (0.92–1.08)

0.90

  1. aAdjusted for age, time period of endoscopy, number of reported endoscopies, time in years since most recent endoscopy and reason for current endoscopy
  2. bAdditionally adjusted for height (inches), body shape at 5 years (1, 2, 3, 4, 5, ≥ 6), dietary intake during adolescence [from high school FFQ: total calories (quintiles), unprocessed red meat and processed meat (quintiles), total dairy (quintiles), and total fibre (quintiles)], current (adult) aspirin use (≥2 or <2 times/week), current (adult) alcohol intake (<4.9, 5–9.9, 10–14.9, 15 + g/d), current (adult) pack-years of smoking (never, 0–10, > 10–20, > 20–40, 40 + pack-years), and family history of CRC (yes/no)
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