Table 3 Odds ratio of colorectal polyp according to total physical activity during adolescence by stage of adenoma and subtype of colorectal polyp. Nurses’ Health Study II, 1997–2011

From: Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses’ Health Study II

 

Total physical activity during adolescence (in MET-h/week)

 < 21

21 to < 36

36 to < 48

48 to < 72

72+

Per 21 MET-h/week

P trend

Colorectal adenoma by stage

 Advanced

   N Cases

105

156

110

106

89

  

   Age-adjusteda

1

1.31 (1.02–1.69)

1.34 (1.02–1.76)

0.98 (0.75–1.29)

0.92 (0.69–1.23)

0.94 (0.88–1.00)

0.07

   Multivariableb

1

1.34 (1.04–1.73)

1.36 (1.03–1.78)

1.00 (0.76–1.32)

0.91 (0.68–1.23)

0.94 (0.88–1.00)

0.06

   Multivariableb plus adult physical activity

1

1.35 (1.05–1.74)

1.38 (1.05–1.81)

1.02 (0.77–1.35)

0.94 (0.70–1.27)

0.95 (0.88–1.01)

0.11

 Non-advanced

   N Cases

294

318

225

257

247

  

   Age-adjusteda

1

0.95 (0.81–1.12)

0.98 (0.82–1.17)

0.85 (0.71–1.01)

0.90 (0.76–1.07)

0.97 (0.93–1.01)

0.16

   Multivariableb

1

0.96 (0.81–1.13)

0.99 (0.83–1.19)

0.86 (0.72–1.02)

0.91 (0.76–1.09)

0.97 (0.93–1.02)

0.21

   Multivariableb plus adult physical activity

1

0.96 (0.81–1.13)

0.99 (0.83–1.19)

0.86 (0.72–1.03)

0.92 (0.77–1.10)

0.97 (0.93–1.02)

0.24

Colorectal polyp by subtype

 Adenoma only

   N Cases

406

490

341

363

331

  

   Age-adjusteda

1

1.06 (0.93–1.22)

1.08 (0.93–1.26)

0.87 (0.75–1.01)

0.88 (0.76–1.03)

0.95 (0.92–0.99)

0.01

   Multivariableb

1

1.07 (0.94–1.23)

1.10 (0.95–1.28)

0.88 (0.76–1.02)

0.90 (0.77–1.05)

0.95 (0.92–0.99)

0.01

   Multivariableb plus adult physical activity

1

1.07 (0.94–1.23)

1.10 (0.95–1.28)

0.89 (0.76–1.03)

0.90 (0.77–1.06)

0.96 (0.92–0.99)

0.02

 Serrated lesions only

   N Cases

339

378

272

347

309

  

   Age-adjusteda

1

0.98 (0.84–1.14)

1.02 (0.87–1.21)

0.99 (0.85–1.16)

0.98 (0.83–1.15)

1.00 (0.96–1.04)

0.85

   Multivariableb

1

0.99 (0.85–1.16)

1.04 (0.88–1.23)

1.01 (0.86–1.18)

0.97 (0.82–1.14)

0.99 (0.95–1.03)

0.69

   Multivariableb plus adult physical activity

1

0.99 (0.85–1.15)

1.04 (0.88–1.23)

1.01 (0.86–1.18)

0.97 (0.83–1.15)

0.99 (0.96–1.03)

0.77

 Both adenoma and serrated lesions

   N Cases

97

89

75

103

78

  

   Age-adjusteda

1

0.81 (0.61–1.09)

1.01 (0.74–1.36)

1.04 (0.79–1.38)

0.89 (0.65–1.20)

1.00 (0.93–1.07)

0.91

   Multivariableb

1

0.81 (0.61–1.09)

0.99 (0.72–1.35)

1.03 (0.77–1.37)

0.84 (0.61–1.14)

0.98 (0.91–1.06)

0.60

   Multivariableb plus adult physical activity

1

0.82 (0.61–1.10)

1.00 (0.73–1.36)

1.05 (0.79–1.40)

0.86 (0.63–1.17)

0.99 (0.92–1.06)

0.74

  1. aAdjusted for age, time period of endoscopy, number of reported endoscopies, time in years since most recent endoscopy and reason for current endoscopy bAdditionally adjusted for height (inches), body shape at age 5 years (1, 2, 3, 4, 5, ≥ 6), dietary intake during adolescence [from high school FFQ: total calories (quintiles), unprocessed red meat and processed meat (quintiles), total dairy (quintiles), and total fibre (quintiles)], current (adult) aspirin use (≥2 or <2 times/week), current (adult) alcohol intake (< 4.9, 5–9.9, 10–14.9, 15 + g/d), current (adult) pack-years of smoking (never, 0–10, > 10–20, > 20–40, 40 + pack-years), and time spent watching TV during adolescence (0.5, 0.5–1, 1–1.5, 1.5–2, 2 + h/day)
  2. Serrated lesions included the following subtypes: hyperplastic polyp, sessile serrated adenoma/polyp, and traditional serrated adenoma
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