Fig. 1 | British Journal of Cancer

Fig. 1

From: The combination of complex karyotype subtypes and IGHV mutational status identifies new prognostic and predictive groups in chronic lymphocytic leukaemia

Fig. 1

In the upper-left panel a the apple-pie graph represents the distribution of patients harbouring type 2 complex karyotype (CK2, 13%), type 1 CK or unmutated IGHV gene (U-CK1, 41%) and mutated IGHV gene without any CK subtypes (M-noCK, 46%). The upper-right panel b shows histograms for frequencies of biological variables among identified subgroups. CK2 subgroups was significantly enriched for CD38 ≥ 30% (CD38+), 11q deletion (11q−), 17p deletions (17p−), TP53 abnormalities (TP53 abn) cases compared to M-noCK or U-CK1 subjects. Panels c–f show Kaplan–Meier curves for survival analysis. Patients with CK2 (light grey curve) had the shortest time to first treatment (c) and overall survival (d) from diagnosis, as well as the worst time to next treatment (e) and overall survival (f) after chemoimmunotherapy with FCR or BR as compared with U-CK1 (dark grey curves) and M-noCK cases (black curves)

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