Table 3 Tumour response, progression-free survival, and overall survival

From: Enhanced antitumor effect of binimetinib in combination with capecitabine for biliary tract cancer patients with mutations in the RAS/RAF/MEK/ERK pathway: phase Ib study

 

Total (n = 34)

Second line (n = 25)

Third line (n = 9)

P-valuea

Response

    

 Complete response

0 (0.0%)

0 (0.0%)

0 (0.0%)

0.988

 Partial response

7 (20.6%)

5 (20.0%)

2 (22.2%)

 

 Stable disease

19 (55.9%)

14 (56.0%)

5 (55.6%)

 

 Progressive disease

8 (23.5%)

6 (24.0%)

2 (22.2%)

 

Objective response rate

20.6%

20.0%

22.2%

 

Disease control rate

76.5%

76.0%

77.8%

 

Progression-free survival

4.1 months (95% CI, 2.8–5.7)

4.4 months (95% CI, 2.9– 5.9)

3.5 months (95% CI, 2.2–4.8)

0.064

Overall survival

7.8 months (95% CI, 5.9–12.2)

7.8 months (95% CI, 5.4–10.2)

6.8 months (95% CI, 5.6–8.0)

0.796

  1. CI confidence interval
  2. aThe comparison between second line and third line