Fig. 2 | British Journal of Cancer

Fig. 2

From: Distinct prognostic value of circulating anti-telomerase CD4+ Th1 immunity and exhausted PD-1+/TIM-3+ T cells in lung cancer

Fig. 2

Relationship between TERT-specific CD4+ Th1 response and blood immune factors in patients with NSCLC. a Heatmap illustrating hierarchical clustering (Euclidean distance) of 22 blood immune parameters (in rows) from NSCLC patients (n = 110) (in columns). b, c Unsupervised principal component analysis (PCA), including frequency (b) and magnitude (c) of anti-TERT Th1 response in relation to 21 blood immune parameters. d, e Representative dot plots (top row) show expressions of PD-1 and/or TIM-3 among CD4+ T cells (d) and CD8+ T cells (e). Histograms show peripheral T-cell expression levels of PD-1, TIM-3 and PD-1+ TIM-3+ among CD4+ T cells (d) and CD8+ T cells (e) from healthy donors (HD, n = 35) and NSCLC patients (n = 109). Median and interquartile range (IQR) are indicated (Mann–Whitney test). *P < 0.05; **P < 0.01. ns not significant

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