Table 2 Colorectal cancer recurrence and overall survival according to tumour risk strata and CD8+ cell density in pooled VICTOR and QUASAR2 trial population
From: Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
No. | No. events | Predicted proportion event free at 3 years | Univariable analysis | Multivariable analysis | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
25th centile CD8+ cell density (95% CI) | 75th centile CD8+ cell density (95% CI) | HR (95% CI) | P | P INTERACTION | HR (95% CI) | P | P INTERACTION | |||
Time to recurrence | ||||||||||
Low risk (pT3, N0) | 453 | 60 | 0.90 (0.88 –0.93) | 0.90 (0.88–0.93) | 1.02 (0.86–1.20) | 0.85 | 0.072 | 1.03 (0.87–1.21) | 0.75 | 0.090 |
Intermediate risk (pT4, N0 or pT1-3, N1/2) | 1035 | 242 | 0.79 (0.76–0.82) | 0.82 (0.80–0.85) | 0.91 (0.85–0.98) | 0.016 | 0.92 (0.86–1.0) | 0.046 | ||
High risk (pT4, N1/2) | 303 | 132 | 0.58 (0.53–0.64) | 0.69 (0.63–0.75) | 0.86 (0.78–0.96) | 4.7 × 10−3 | 0.87 (0.79–0.97) | 9.4 × 10−3 | ||
Overall survival | ||||||||||
Low risk (pT3, N0) | 453 | 52 | 0.95 (0.94–0.97) | 0.95 (0.93–0.96) | 1.03 (0.87–1.23) | 0.72 | 0.051 | 1.04 (0.87–1.24) | 0.69 | 0.056 |
Intermediate risk (pT4, N0 or pT1-3, N1/2) | 1035 | 177 | 0.89 (0.87–0.91) | 0.90 (0.88–0.92) | 0.94 (0.86–1.03) | 0.20 | 0.94 (0.86–1.03) | 0.22 | ||
High risk (pT4, N1/2) | 303 | 120 | 0.75 (0.71–0.80) | 0.82 (0.78–0.86) | 0.88 (0.79–0.97) | 0.017 | 0.88 (0.79–0.98) | 0.022 | ||
