Table 2 Clinical characteristics of study population by histology (only reviewed slide cases; n = 635)

From: Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma

Variable

Histology

p-value*

SRCC

%

AC with SC

%

AC

%

Gender

       

 Female

18

51.4

14

50.0

245

42.8

0.32

 Male

17

48.6

14

50.0

327

57.2

Age

       

 15–39

7

20.0

2

7.1

53

9.3

0.10

 40–49

9

25.7

6

21.4

136

23.8

 ≥50

19

54.3

20

71.4

383

67.0

Site (n = 602)

       

 Right-sided

22

62.9

12

42.9

189

33.3

0.001

 Left-sided

13

37.1

16

57.1

378

66.7

Race (n = 602)

       

  Asian

1

2.9

0

0.0

32

5.6

0.43

  Black

4

11.8

2

7.1

53

9.3

  Hispanic

2

5.9

2

7.1

53

9.3

  White

27

79.4

24

85.7

430

75.7

Differentiated (n = 601)

       

 Well-moderately

0

0.0

0

0.0

449

79.3

<0.001

 Poorly

35

100

28

100

117

20.7

Liver metastasis

       

 No

29

82.9

`15

53.6

132

23.1

<0.001

 Yes

6

17.1

13

46.4

440

76.9

Lung metastasis

       

 No

29

82.9

22

78.6

184

32.2

<0.001

 Yes

6

17.1

6

21.4

388

67.8

Peritoneal metastasis

       

 No

6

17.1

7

25.0

383

67.0

<0.001

 Yes

29

82.9

21

75.0

189

33.0

MMR status (n = 472)

       

 pMMR

29

87.9

19

90.5

404

95.1

0.10

 dMMR

4

12.1

2

9.5

21

4.9

CIMP (n = 215)

       

 CIMP-L/neg

2

66.7

5

71.4

175

75.1

–a

 CIMP-H

1

33.3

2

28.6

58

24.9

  1. The Bold values are statistically significant
  2. A p-value < 0.05 indicates statistical significance
  3. SRCC signet ring cell colorectal cancer, AC with SC adenocarcinoma with signet ring cell component, AC adenocarcinoma
  4. *p-value for SRCC compared with AC
  5. aNo statistical analysis due to small sample size
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