Fig. 4
From: Metabolic rewiring and redox alterations in malignant pleural mesothelioma
Schematic diagram of the MTAP pathway. a. 5′-methylthioadenosine phosphorylase (MTAP) converts MTA into adenine and 5-methylthioribose-1-phosphate (5-MTR-1-P). b. Loss of MTAP results in accumulation of MTA, which inhibits protein arginine transferase 5 (PRMT5), an enzyme involved in the methylation of Sm proteins and histones.
