Fig. 1: PKM2 overexpression correlates with poor prognosis in PDAC. | British Journal of Cancer

Fig. 1: PKM2 overexpression correlates with poor prognosis in PDAC.

From: Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)

Fig. 1

a Heatmap analysis of overexpression of PKM2 vs PKLR in pancreatic tumour tissue vs healthy tissue from the same resected margin from PDAC patients. Data mining was performed on publicly available gene chip microarray data from Badea Pancreas(25) using Oncomine. b Box and whisker plot displaying PKM2 expression in tumour tissue vs healthy pancreas (unpaired t test; n = 39). c Kaplan–Meier survival analysis of PDAC patients with median-centred high vs low expression of PKM2 (hazard ratio = 1.88 (1.19–2.97), n = 51, p < 0.008; data generated using PROGgeneV2, proportional hazards analysis).

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