Table 4 Clinicopathological characteristics of PDAC patients with and without ctDNA KRAS G12D mutations in discover cohort.
Variable | ctDNA KRAS G12D mutation | P | |
|---|---|---|---|
Negative (N = 100) | Positive (N = 13) | ||
Sex | |||
Female (%) | 38 (86.4%) | 6 (13.6%) | 0.571 |
Male (%) | 62 (89.9%) | 7 (10.1%) | |
Age at surgery, y | |||
<70 (%) | 78 (87.6%) | 11 (12.4%) | 0.732 |
≥70 (%) | 22 (91.7%) | 2 (8.3%) | |
Smoking history | |||
No (%) | 88 (88.0%) | 12 (12.0%) | 1 |
Yes (%) | 12 (92.3%) | 1 (7.7%) | |
Drinking history | |||
No (%) | 90 (87.4%) | 13 (12.6%) | 0.602 |
Yes (%) | 10 (100.0%) | 0 (0.0%) | |
Diabetes mellitus | |||
No (%) | 73 (91.2%) | 7 (8.8%) | 0.153 |
Yes (%) | 27 (81.8%) | 6 (18.2%) | |
First clinical symptom | |||
Abdominal pain | 0.692 | ||
No (%) | 48 (87.3%) | 7 (12.7%) | |
Yes (%) | 52 (89.7%) | 6 (10.3%) | |
First clinical symptom | |||
Jaundice | 0.883 | ||
No (%) | 56 (88.9%) | 7 (11.1%) | |
Yes (%) | 44 (88.0%) | 6 (12.0%) | |
CEA at diagnosis | |||
Normal (%) | 70 (86.4%) | 11 (13.6%) | 0.344 |
Elevated (%) | 30 (93.7%) | 2 (6.3%) | |
CA19-9 at diagnosis | |||
Normal (%) | 21 (95.5%) | 1 (4.5%) | 0.457 |
Elevated (%) | 79 (86.8%) | 12 (13.2%) | |
Pancreatectomy type | |||
Distal pancreatectomy (%) | 31 (86.1%) | 5 (13.9%) | 0.587 |
Pancreaticoduodenectomy (%) | 69 (89.6%) | 8 (10.4%) | |
Radiologic tumour size, cm | |||
≤2 (%) | 25 (92.6%) | 2 (7.4%) | 0.374 |
>2, ≤4 (%) | 59 (88.1%) | 8 (11.9%) | |
>4 (%) | 16 (84.2%) | 3 (15.8%) | |
Differentiation degree | |||
Poor (%) | 31 (86.1%) | 5 (13.9%) | 0.587 |
Medium/well (%) | 69 (89.6%) | 8 (10.4%) | |
Perineural invasion | |||
No (%) | 18 (78.3%) | 5 (21.7%) | 0.085 |
Yes (%) | 82 (91.1%) | 8 (8.9%) | |
Pathological stage (AJCC, 8th edition) | |||
IA (%) | 14 (93.3%) | 1 (6.7%) | 0.661 |
IB (%) | 30 (88.2%) | 4 (11.8%) | |
IIA (%) | 12 (85.7%) | 2 (14.3%) | |
IIB (%) | 38 (88.4%) | 5 (11,6%) | |
III (%) | 6 (85.7%) | 1 (14.3%) | |
Adjuvant chemotherapy | |||
No (%) | 6 (100.0%) | 0 (0.0%) | 1 |
Yes (%) | 94 (87.9%) | 13 (12.1%) | |
Recurrent disease | |||
No (%) | 9 (100.0%) | 0 (0.0%) | 0.595 |
Yes (%) | 91 (87.5%) | 13 (12.5%) | |
Recurrence types | |||
Local (%) | 36 (97.3%) | 1 (2.7%) | 0.018 |
Distant (%) | 46 (79.3%) | 12 (20.7%) | |
Both (%) | 9 (100.0%) | 0 (0.0%) | |
