Table 1 Characteristics between adolescent and young adult cancer survivor group and comparison group.

From: Adverse birth outcomes in adolescent and young adult female cancer survivors: a nationwide population-based study

Characteristics

No. (%) of births

 

Comparison group N = 45,463 to 45,120 mothers

Cancer survivor group N = 4547 to 3531 mothers

P value

Maternal age at delivery

  

>0.99

  15–24 years

1480 (3.3)

148 (3.3)

 

  25–34 years

28,820 (63.4)

2882 (63.4)

 

  ≥35 years (max. 48 years)

15,163 (33.4)

1517 (33.4)

 

  Median

33.0 years

33.0 years

 

Infant gender

  

0.355

 Female

21,680 (47.7)

2201 (48.4)

 

Infant birth year

  

>0.99

 2004–2007

12,712 (28.0)

1272 (28.0)

 

 2008–2011

16,122 (35.5)

1612 (35.5)

 

 2012–2014

16,629 (36.6)

1663 (36.5)

 

Maternal comorbidity

 Cardiovascular disease

290 (0.6)

62 (1.4)

<0.001

 Autoimmune disease

507 (1.1)

72 (1.6)

0.007

 Liver disease

669 (1.5)

205 (4.5)

<0.001

 Hypertension

656 (1.3)

92 (2.0)

0.003

 Diabetes mellitus before pregnancy

768 (1.7)

103 (2.27)

0.007

 Gestational diabetes mellitus

1469 (3.0)

166 (3.7)

0.136

Maternal lifestyle

 Smoking during pregnancy

41 (0.1)

–a

0.267

 Alcohol misuse during pregnancy

8 (0.0)

–a

0.217

Maternal selective serotonin reuptake inhibitor use during pregnancyb

270 (0.6)

25 (0.6)

0.708

Maternal category D and X medication use during pregnancyb

53 (0.1)

4 (0.1)

0.571

Maternal cancer types

 Thyroid cancer

 

1584 (34.8)

 

  Gynaecologic cancer

 

725 (15.9)

 

  Breast cancer

 

691 (15.2)

 

  Others

 

1547 (34.0)

 

Maternal cancer treatments

 No CT or RT

–

3045 (67.0)

 

 RT alone

–

84 (1.9)

 

 CT with or without RT

–

1418 (31.2)

 

Maternal nationality

  

<0.001

 Taiwan

42,698 (93.9)

4465 (98.2)

 

Maternal place of residence

  

<0.001

  Urban

39,031 (85.9)

4002 (88.0)

 

  Suburban

5433 (12.0)

471 (10.4)

 

  Rural

999 (2.2)

74 (1.6)

 

Maternal income levels (New Taiwan Dollar)c

  

<0.001

  Quintile 1 (≤21,900)

4983 (11.0)

375 (8.25)

 

  Quintile 2 (22,800–28,000)

10,588 (23.3)

1123 (24.7)

 

  Quintile 3 (30,300–40,100)

9767 (21.5)

941 (20.7)

 

  Quintile 4 (42,000–53,000)

8677 (19.1)

912 (20.1)

 

  Quintile 5 (≥55,400)

11,448 (25.2)

1196 (26.3)

 

Maternal occupation

  

<0.001

  Dependents of the insured individuals

26,424 (58.12)

2693 (59.23)

 

  Civil servants, teachers, military personnel and veterans

2144 (4.72)

254 (5.59)

 

  Non-manual workers and professionals

14,702 (32.34)

1343 (29.54)

 

  Manual workers/others

2193 (4.82)

257 (5.65)

 
  1. aNumbers <3 are not displayed, as per the confidentiality policies of National Health Insurance Database
  2. bFrom 90 days before the date of the last menstrual period to the birth date
  3. cMaternal income levels were estimated by insurance premium using sex-specific quintiles in Taiwan from low to high
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