Table 2 Adverse birth outcomes of infants in the female adolescent and young adult (AYA) cancer survivor group and the comparison group.

From: Adverse birth outcomes in adolescent and young adult female cancer survivors: a nationwide population-based study

 

Comparison group

N = 45,463

AYA cancer survivor group

N = 4567

Crude odds ratio (95% CI)

Adjusted odds ratioa

Model 1 (95% CI)

Adjusted odds ratiob

Model 2 (95% CI)

 

N (%)

N (%)

   

Overall adverse birth outcomec

15,436 (33.95)

1643 (36.13)

1.1 (1.03–1.18)

1.1 (1.03–1.18)

1.09 (1.02–1.16)

  Stillbirth

391 (0.86)

41 (0.90)

1.05 (0.76–1.45)

1.04 (0.75–1.43)

1.01 (0.74–1.40)

  Low birth weight

3121 (6.86)

366 (8.05)

1.19 (1.06–1.34)

1.18 (1.05–1.32)

1.15 (1.02–1.30)

  Preterm labour

3788 (8.33)

439 (9.65)

1.16 (1.04–1.29)

1.15 (1.04–1.29)

1.12 (1.00–1.25)

  Small for gestational age

4109 (9.04)

436 (9.59)

1.08 (0.97–1.20)

1.07 (0.96–1.19)

1.07 (0.96–1.19)

  Large for gestational age

4965 (10.92)

511 (11.24)

1.03 (0.93–1.14)

1.04 (0.94–1.16)

1.03 (0.93–1.14)

  5-min Apgar score <7

480 (1.06)

57 (1.25)

1.19 (0.90–1.57)

1.19 (0.90–1.57)

1.14 (0.86–1.51)

  Congenital malformation

2817 (6.20)

289 (6.36)

1.03 (0.91–1.18)

1.01 (0.89–1.15)

1.01 (0.89–1.15)

  Foetal distress

2205 (4.85)

250 (5.50)

1.14 (0.99–1.31)

1.14 (0.99–1.31)

1.14 (0.99–1.31)

Caesarean delivery

17,297 (38.05)

1889 (41.54)

1.2 (1.12–1.28)

1.19 (1.11–1.27)

1.18 (1.10–1.27)

  1. aModel 1: Maternal age at delivery, infant sex, infant birth year, maternal alcohol misuse during pregnancy, maternal smoking during pregnancy, maternal nationality, maternal place of residence, maternal income level, maternal occupation
  2. bModel 2: Model 1 + maternal cardiovascular disease, maternal autoimmune disease, maternal liver disease, maternal hypertension, maternal diabetes mellitus before pregnancy, maternal gestational diabetes mellitus, maternal bipolar disorder, maternal selective serotonin reuptake inhibitor use during pregnancy, maternal category D and X medication use during pregnancy
  3. cCaesarean delivery excluded