Table 3 Adverse birth outcomes in different anticancer treatment groups and the comparison group.

From: Adverse birth outcomes in adolescent and young adult female cancer survivors: a nationwide population-based study

 

Comparison group N = 45,463

Cancer survivor group

  

Neither RT nor chemotherapy

N = 3045

Adjusted odds ratioa (95% CI)

RT alone

N = 84

Adjusted odds ratioa (95% CI)

Chemotherapy ± RT N = 1418

Adjusted odds ratioa (95% CI)

 

N (%)

N (%)

 

N (%)

 

N (%)

 

Overall adverse birth outcomeb

15,436 (33.95)

1079 (35.44)

1.06 (0.98–1.15)

46 (54.76)

2.42 (1.52–3.85)

518 (36.53)

1.09 (0.98–1.22)

  Stillbirth

391 (0.86)

26 (0.85)

0.97 (0.65–1.45)

0 (0)

NA

15 (1.06)

1.16 (0.70–1.93)

  Low birth weight

3121 (6.86)

229 (7.52)

1.08 (0.94–1.26)

12 (14.29)

2.25 (1.20–4.23)

125 (8.82)

1.23 (1.01–1.50)

  Preterm labour

3788 (8.33)

280 (9.20)

1.07 (0.93.22)

16 (19.05)

2.40 (1.28–4.49)

143 (10.08)

1.17 (0.97–1.40)

  Small for gestational age

4109 (9.04)

298 (9.79)

1.10 (0.97–1.25)

10 (11.90)

1.53 (0.79–2.94)

128 (9.03)

0.98 (0.81–1.19)

  Large for gestational age

4965 (10.92)

335 (11.00)

1.01 (0.89–1.14)

12 (14.29)

1.34 (0.71–2.54)

164 (11.57)

1.06 (0.89–1.26)

  5-min Apgar score of <7

480 (1.06)

35 (1.15)

1.09 (0.76–1.55)

–c

3.63 (1.20–10.99)

19 (1.34)

1.12 (0.70–1.77)

  Congenital malformation

2817 (6.20)

177 (5.81)

0.94 (0.80–1.10)

8 (9.52)

1.66 (0.77–3.59)

104 (7.33)

1.13 (0.91–1.39)

  Foetal distress

2205 (4.85)

167 (5.48)

1.13 (0.96–1.34)

10 (11.90)

2.79 (1.42–5.45)

73 (5.15)

1.06 (0.83–1.36)

Caesarean delivery

17,297 (38.05)

1225 (40.23)

1.13 (1.04–1.22)

48 (57.14)

2.02 (1.32–3.09)

616 (43.44)

1.26 (1.11–1.42)

  1. aAdjusted for maternal age at delivery, infant sex, infant birth year, maternal cardiovascular disease, maternal autoimmune disease, maternal liver disease, maternal hypertension, maternal diabetes mellitus before pregnancy, maternal gestational diabetes mellitus, maternal bipolar disorder, maternal alcohol misuse during pregnancy, maternal smoking during pregnancy, maternal selective serotonin reuptake inhibitor use during pregnancy, maternal category D and X medication use during pregnancy, maternal nationality, maternal place of residence, maternal income level, maternal occupation
  2. bCaesarean delivery excluded
  3. cNumbers <3 are not displayed, as per the confidentiality policies of National Health Insurance Database
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