Fig. 5
Overview plots of HRs (with 95% CIs) for all possible cut-off values for tdEV counts in CRPC (a), MBC (b) and mCRC (c) patients with favourable CTC counts (<5 for CRPC and MBC and <3 for mCRC), as generated by the Cutoff Finder software. The optimal cut-offs, determined as the point that resulted in the most significant split (log-rank test), are indicated by a vertical line in each plot. Kaplan–Meier plots for overall survival in CRPC (d), MBC (e) and mCRC (f) patients with favourable CTC counts by favourable and unfavourable tdEV counts were generated based on the optimal tdEV cut-off values. Favourable CTC patients with unfavourable (elevated) tdEV counts had significantly worse OS compared to favourable CTC patients with favourable (below the selected cut-off values) tdEV counts.
