Table 1 Patient characteristics.

From: Tumour-derived extracellular vesicles in blood of metastatic cancer patients associate with overall survival

Metastatic cancer patients

CRPCa

MBC

mCRC

NSCLC

Number of patients

190

179

450

137

Age (years)

  Median (range)

70 (49–92)

59 (27–86)

63 (27–83)

65 (29–83)

Gender

  Male

190 (100%)

0 (0%)

271 (60%)

74 (54%)

  Female

0 (0%)

179 (100%)

179 (40%)

63 (46%)

  Unknown

0 (0%)

0 (0%)

0 (0%)

0 (0%)

ECOG performance status

  0

87 (46%)

83 (46%)

286 (64%)

78 (57%)

  1

80 (42%)

73 (41%)

153 (34%)

49 (36%)

  2

17 (9%)

17 (10%)

2 (0%)

5 (4%)

  3

0 (0%)

1 (1%)

  

  4

0 (0%)

0 (0%)

  

  Unknown

6 (3%)

5 (3%)

9 (2%)

5 (4%)

Line of therapy

  1

132 (70%)

75 (42%)

450 (100%)

36 (26%)

  2

29 (15%)

27 (15%)

 

21 (15%)

  3+

29 (15%)

75 (42%)

 

80 (59%)

  Unknown

 

2 (1%)

  

Therapy type started after blood draw

  Chemotherapy

11 (6%)

75 (42%)

 

32 (23%)

  Hormone

 

45 (25%)

  

  Molecular

 

8 (4%)

 

20 (15%)

  Immunotherapy

   

80 (58%)

  Other

 

1 (1%)

  

  Chemotherapy/hormone

126 (66%)

11 (6%)

  

  Chemotherapy/molecular

 

23 (13%)

450 (100%)

 

  Chemotherapy/other

7 (4%)

1 (1%)

  

  Hormone/molecular

 

8 (4%)

  

  Chemotherapy/molecular/hormone

 

2 (1%)

  

  Chemotherapy/hormone/other

45 (24%)

   

  Unknown

1 (1%)

5 (3%)

 

5 (4%)

Follow-up time (in months), median (min–max)

  Alive

30.4 (1.9–39.0)

20.6 (1.3–48.8)

20.2 (0.0–34.0)

8.8 (0.7–30.1)

  Dead

11.6 (0.7–39.3)

9.9 (0.4–31.7)

12.2 (0.4–32.3)

4.6 (0.7–25.3)

Status at last follow-up

  Alive

53 (28%)

77 (43%)

194 (43%)

68 (50%)

  Dead

137 (72%)

102 (57%)

256 (57%)

69 (50%)

  1. aIn case of CRPC, the line of therapy refers to the line of cytotoxic therapy