Table 1 Toxicity categories used in the phase I study reports examined, as per the Common Terminology Criteria for Adverse Events, version 4.0.
Toxicity category | Common human toxicities | Common animal toxicities |
|---|---|---|
Cardiovascular | Hypertension, tachycardia, bradycardia, dyslipidemia | Tachycardia, bradycardia |
Cutaneous | Rash, alopecia | Rash, fur discoloration |
Endocrine | Diabetes | Increase in endocrine system organs |
Gastrointestinal | Nausea, vomiting, diarrhoea | Loose stool |
General | Fatigue, fever, chills | Decreased activity |
Haematologic | Neutropenia, thrombocytopenia | Changes in red blood cells or white blood cells |
Hepatic | Changes in alanine transaminase or aspartate transaminase | Changes in alanine transaminase or aspartate transaminase |
Metabolic | Anorexia, decreased appetite, hyperglycaemia | Decreased food consumption |
Musculoskeletal | Muscle pain, back pain | Awkward gait, hunched posture |
Neurologic/psychiatric | Headache, insomnia | Tremors |
Ocular | Blurred vision | Bloody tears |
Renal | Changes in creatinine or blood urea nitrogen | Blood in urine |
Respiratory | Cough, shortness of breath | Laboured breathing |
