Table 1 Baseline characteristics of randomly assigned patients.

From: Chemoradiotherapy with extended nodal irradiation and/or erlotinib in locally advanced oesophageal squamous cell cancer: long-term update of a randomised phase 3 trial

Characteristics

No. (%)

Group A (n = 88)

Group B (n = 88)

Group C (n = 88)

Group D (n = 88)

p

  

N (%)

N (%)

N (%)

N (%)

Sex

 Male

288 (81.8)

72 (81.8)

76 (86.4)

68 (77.3)

72 (81.8)

0.486

 Female

64 (18.2)

16 (18.2)

12 (13.6)

20 (22.7)

16 (18.2)

 

Age (years)

 Median

61

61

61

61

62

0.770

 Range

35–70

35–70

40–68

40–70

41–70

 

Tumour length (cm)

 Median

5.3

5

5.3

6

5.6

0.130

 Range

1.2–15

1.5–14

2–15

1.2–11.2

2.9–12

 

T stage

 T1

11 (3.1)

1 (1.1)

2 (2.3)

6 (6.8)

2 (2.3)

0.067

 T2

47 (13.4)

19 (21.6)

10 (11.4)

11 (12.5)

7 (8.0)

 

 T3

193 (54.8)

48 (54.5)

45 (51.1)

50 (56.8)

50 (56.8)

 

 T4

101 (28.7)

20 (22.7)

31 (35.2)

21 (23.9)

29 (33.0)

 

N stage

 N−

149 (42.3)

39 (44.3)

33 (37.5)

40 (45.5)

37 (42.0)

0.730

 N+

203 (57.7)

49 (55.7)

55 (62.5)

48 (54.5)

51 (58.0)

 

ECOG PS

 0–1

218 (61.9)

55 (62.5)

54 (61.4)

55 (62.5)

54 (61.4)

0.995

 2

134 (38.1)

33 (37.5)

34 (38.6)

33 (37.5)

34 (38.6)

 

Tumour location

 Cervical

21 (6.0)

4 (4.5)

6 (1.7)

5 (5.7)

6 (6.8)

0.999

 Upper thoracic

103 (29.3)

24 (27.3)

26 (7.4)

27 (30.7)

26 (29.5)

 

 Middle thoracic

195 (55.4)

51 (58.0)

48 (13.7)

47 (53.4)

49 (55.7)

 

 Lower thoracic

33 (9.4)

9 (10.2)

8 (2.3)

9 (10.2)

7 (8.0)

 

EGFR expression

 Unknow

262 (74.4)

64 (72.7)

65 (73.9)

67 (76.1)

66 (75.0)

0.441

 0

16 (4.5)

2 (2.3)

5 (5.7)

2 (2.3)

7 (8.0)

 

 1+

23 (6.5)

6 (6.8)

8 (9.1)

6 (6.8)

3 (3.4)

 

 2+

31 (8.8)

9 (10.2)

6 (6.8)

6 (6.8)

10 (11.4)

 

 3+

20 (5.7)

7 (8.0)

4 (4.5)

7 (8.0)

2 (2.3)

 
  1. N number of patients, Group A chemotherapy/extended nodal irradiation + erlotinib, Group B chemotherapy/extended nodal irradiation, Group C chemotherapy/conventional field irradiation + erlotinib, Group D chemotherapy/conventional field irradiation, ECOG PS Eastern Cooperative Oncology Group performance status, EGFR epidermal growth factor receptor.