Table 1 The cutoff criteria for evaluation of true positive and false-positive rates.

From: CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma

  

Cutoff (number of sgRNAs with 4-fold reduction)

 

Total

>1

>2

>3

>4

Essential genes

216

138

67

25

5

Non-essential genes

771

105

15

2

0

False-negative rate:

 

36.1%

69.0%

88.4%

97.7%

False-positive rate:

 

13.6%

1.9%

0.3%

0.0%

Back to article page