Fig. 4: CDX2 inhibits Snail expression through suppressing PI3K/Akt/GSK-3β activity. | British Journal of Cancer

Fig. 4: CDX2 inhibits Snail expression through suppressing PI3K/Akt/GSK-3β activity.

From: CDX2 inhibits epithelial–mesenchymal transition in colorectal cancer by modulation of Snail expression and β-catenin stabilisation via transactivation of PTEN expression

Fig. 4

a Pathway analysis of genes that were significantly and differentially expressed in SW480-shCDX2 and control cells using KEGG database. b Western blotting bands for AKT/p-AKT (Thr308/Ser473), GSK-3β/p-GSK-3β (Ser9) and Erk1/2/p-Erk1/2 (Thr202/Tyr204) in CDX2-knockdown and -overexpressing cells. c Transwell assays in CDX2-knockdown cells treated with MK-2206. d Western blotting bands for PI3K/Akt signalling- and EMT-related proteins and in CDX2-knockdown cells treated with MK-2206. All data are presented as the mean ± SD from three independent experiments. *P < 0.05.

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