Fig. 6: CDX2 transactivates the expression of PTEN by binding to the PTEN promoter in colon cancer cells. | British Journal of Cancer

Fig. 6: CDX2 transactivates the expression of PTEN by binding to the PTEN promoter in colon cancer cells.

From: CDX2 inhibits epithelial–mesenchymal transition in colorectal cancer by modulation of Snail expression and β-catenin stabilisation via transactivation of PTEN expression

Fig. 6

a, b The activities of the PTEN full promoter reporter construct and the truncated ones in CDX2-overexpression Lovo (a) and Caco-2 (b) cells using the dual-luciferase assay. c Schematic representation of the CDX2 putative binding sites (P1–P4) in PTEN promoter region. d, e Enrichment level of the CDX2- binding putative site in the PTEN promoter region in Lovo (d) and Caco-2 (e) cells determined by the qChIP assay. All data are presented as the mean ± SD from three independent experiments. *P < 0.05.

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