Table 2 Odds Ratios (ORs) and 95% confidence intervals (95% CIs) for risk of colorectal adenoma according to quintiles of dairy intake during high school, NHS2 1998–2011.

From: Dairy intake during adolescence and risk of colorectal adenoma later in life

 

Dairy intake during high school (servings/day)

 
 

Q1

Q2

Q3

Q4

Q5

Ptrend

 

≤1.42

1.43–2.20

2.21–3.14

3.15–3.99

≥4.00

 

All adenomas

N cases

446

420

480

476

417

 

Age-adjusted*

1 (Reference)

0.96 (0.84, 1.10)

1.07 (0.93, 1.22)

1.01 (0.89, 1.16)

1.02 (0.89, 1.18)

0.52

Multivariable†

1 (Reference)

0.92 (0.80, 1.06)

1.02 (0.88, 1.17)

0.96 (0.83, 1.11)

0.98 (0.84, 1.15)

0.94

Multivariable† plus adult diet

1 (Reference)

0.91 (0.79, 1.05)

1.00 (0.86, 1.15)

0.93 (0.80, 1.08)

0.94 (0.80, 1.11)

0.64

Proximal adenomas

N cases

217

215

226

264

206

 

Multivariable† plus adult diet

1 (Reference)

0.96 (0.79, 1.18)

0.99 (0.80, 1.21)

1.08 (0.88, 1.33)

1.01 (0.80, 1.28)

0.56

Distal adenomas

N cases

195

185

200

195

184

 

Multivariable† plus adult diet

1 (Reference)

0.93 (0.75, 1.15)

0.97 (0.78, 1.20)

0.90 (0.71, 1.13)

0.97 (0.76, 1.24)

0.79

Rectal adenomas

N cases

76

63

103

72

53

 

Multivariable† plus adult diet

1 (Reference)

0.80 (0.57, 1.12)

1.23 (0.89, 1.70)

0.79 (0.55, 1.13)

0.63 (0.42, 0.95)

0.04

Small, tubular adenomas (non-advanced)

N cases

239

243

263

285

248

 

Multivariable† plus adult diet

1 (Reference)

0.97 (0.80, 1.18)

1.02 (0.84, 1.24)

1.04 (0.86, 1.27)

1.07 (0.86, 1.33)

0.39

Large or villous adenomas (advanced)

N cases

114

97

122

99

84

 

Multivariable† plus adult diet

1 (Reference)

0.83 (0.63, 1.10)

1.01 (0.76, 1.33)

0.76 (0.56, 1.04)

0.72 (0.51, 1.00)

0.05

Single adenoma

N cases

353

329

370

369

342

 

Multivariable† plus adult diet

1 (Reference)

0.90 (0.76, 1.05)

0.96 (0.81, 1.13)

0.89 (0.75, 1.05)

0.95 (0.79, 1.14)

0.64

Two or more adenomas

N cases

88

87

108

103

68

 

Multivariable† plus adult diet

1 (Reference)

0.99 (0.73, 1.34)

1.22 (0.91, 1.65)

1.13 (0.83, 1.55)

0.90 (0.63, 1.29)

0.88

  1. *Adjusted for age, time period of endoscopy, number of reported endoscopies, time in years since most recent endoscopy and reason for current endoscopy.
  2. †Additionally adjusted for BMI at age 18 years (<18, 18–20.9, 21–22.9, 23–24.9, ≥25 kg/m2), current physical activity (<21, 21–<30, 30–<39, 39–<54, ≥54 MET hours/week), physical activity during 9th–12th grades (quintiles), current alcohol intake (<5, 5–9.9, 10–14.9, 15–29.9, 30+ g/d), pack-years of smoking (never, 1–4.9, 5–19.9, 20–39.9, 40+ pack-years), regular aspirin use (≥2 tablets/week vs. <2/week), menopausal status/postmenopausal hormone use (premenopausal, postmenopausal with current hormone use, postmenopausal without current hormone use), family history of colorectal cancer, total calories during high school (quintiles) and intake of unprocessed red meat and processed meat during high school (quintiles).
  3. plus adult diet = adult calorie (quintiles) and total dairy intake (quintiles).
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