Fig. 1: Small molecule inhibition of USP10 leads to degradation of SYK and targeted killing of activated SYK-driven cells. | British Journal of Cancer

Fig. 1: Small molecule inhibition of USP10 leads to degradation of SYK and targeted killing of activated SYK-driven cells.

From: Inhibition of the deubiquitinase USP10 induces degradation of SYK

Fig. 1

a, b Immunoblots: Effects of 24 h of treatment with HBX19818 or P22077 on FLT3 and SYK protein levels in Ba/F3-FLT3-ITD (a) or MV4-11 cells (b). c Immunoblots: Effects of 24 h of treatment with HBX19818 or P22077 on SYK protein levels in PBMCs from normal donors. d, e Proliferation assay: 2-day treatment of Ba/F3 versus Ba/F3-SYK-TEL cells with USP10-targeting inhibitors, C673-0105 (d) and C598-0556 (e). f Immunoblots: Effects of 24 h of treatment with C673-0105 and C598-0556 on SYK protein levels in Ba/F3-SYK-TEL cells.

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