Table 2 Adverse events possibly, probably or definitively related to tivozanib (n, %).
Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | Total | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fatigue | 6 | 22 | 4 | 15 | 7 | 26 | 0 | 0 | 0 | 0 | 17 | 63 |
Diarrhoea | 6 | 22 | 5 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 41 |
Decreased appetite | 3 | 11 | 6 | 22 | 1 | 4 | 0 | 0 | 0 | 0 | 10 | 37 |
Nausea | 4 | 15 | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 26 |
Dysphonia | 6 | 22 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 26 |
Vomiting | 4 | 15 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 22 |
Stomatitis | 4 | 15 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 19 |
Elevated bilirubin | 0 | 0 | 3 | 11 | 2 | 7 | 0 | 0 | 0 | 0 | 5 | 18 |
Hypertension | 1 | 4 | 1 | 4 | 2 | 7 | 1 | 4 | 0 | 0 | 5 | 19 |
Thrombocytopenia | 4 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 15 |
Increased ALP | 0 | 0 | 0 | 0 | 3 | 11 | 0 | 0 | 0 | 0 | 3 | 11 |
Lymphocytopenia | 1 | 4 | 1 | 4 | 1 | 4 | 0 | 0 | 0 | 0 | 3 | 12 |
Epistaxis | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 11 |
Pulmonary embolism | 0 | 0 | 0 | 0 | 3 | 11 | 0 | 0 | 0 | 0 | 3 | 11 |
PPEDS | 2 | 7 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 3 | 11 |
Increased ALT | 1 | 4 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 2 | 8 |
Decreased weight | 0 | 0 | 1 | 4 | 1 | 4 | 0 | 0 | 0 | 0 | 2 | 8 |
Dizziness | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 7 |
Headache | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 8 |
Dry skin | 1 | 4 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 7 |
Pruritus | 1 | 4 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 8 |
