Fig. 2: Effects of nintedanib on CAFs and ICC cells. | British Journal of Cancer

Fig. 2: Effects of nintedanib on CAFs and ICC cells.

From: Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts

Fig. 2

a Nintedanib inhibits the proliferation of CAFs concentration-dependently (n = 5). *P < 0.01. b Nintedanib inhibits the proliferation of HuCCT1 and RBE only at high concentrations (n = 5). *P < 0.01. c α-SMA expression in CAFs treated with nintedanib is evaluated by western blotting. CAFs were pre-activated with 5 ng ml−1 TGF-b1. β-actin is used as the loading control. *P < 0.01.

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