Table 3 Univariable and multivariable Cox proportional hazard regression analysis of patients cancer-specific survival.

From: HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis

Variables

Univariable Analysis

Multivariable analysis

P

HR (95% CI)

P

HR (95% CI)

HHLA2-expression

 Absent vs low

0.024

0.629 (0.421–0.940)

0.022

0.601 (0.389–0.929)

 Absent vs high

0.000

0.371 (0.227–0.607)

0.011

0.471 (0.264–0.839)

T-stage (T1 vs T2, T3, T4)

0.012

1.992 (1.163–3.411)

0.555

1.187 (0.672–2.096)

Tumour differentiation

 Poor vs moderate

0.784

0.915 (0.486–1.724)

0.666

0.855 (0.419–1.742)

 Poor vs well-differentiated

0.046

1.946 (1.010–3.761)

0.005

0.561 (0.377–0.836)

Margin Status

0.000

2.212 (1.564–3.127)

0.000

2.003 (1.360–2.950)

Lymph node status

0.000

2.844 (1.946–4.157)

0.000

2.734 (1.797–4.160)

Ca19-9 (>37 vs<37 kU/L)

0.001

1.940 (1.321–2.850)

0.297

1.264 (0.814–1.962)

Pancreas vs Ampulla

0.001

1.873 (1.292–2.715)

0.623

1.119 (0.715–1.750)

Systemic chemotherapy

0.058

1.408 (0.989–2.005)

0.600

1.110 (0.751–1.642)

Age, yrs

0.095

0.985 (0.967–1.003)

0.310

0.990 (0.970–1.010)

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