Fig. 1: Performance of the 7 different gene panels in exome-based TMB determination and the relation between TMB and ML for different types of cancer.

a Receiver operating characteristic (ROC) curves for each gene panel compared to exome-based TMB for all tumour types in the cohort. Exome-based TMB was dichotomised at a 10/Mb cut-point. b ROC curves for each gene panel compared to exome-based TMB for colorectal cancer, skin cancer, lung cancer and breast cancer, respectively. Exome-based TMB was dichotomised at a 10/Mb cut-point. c For each tumour biopsy sequenced, mutational load is plotted against exome-based TMB. Linear regression lines are fitted on the colorectal cancer, skin cancer, lung cancer and breast cancer datasets, respectively. Goodness of fit (R²) and equations for the regression lines of these four tumour types are depicted in the graph.