Fig. 3: GWAS approach to identify the genetic modifiers in ACC age-of-onset. | British Journal of Cancer

Fig. 3: GWAS approach to identify the genetic modifiers in ACC age-of-onset.

From: A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence

Fig. 3

a A flow chart representing the focused analytical approach taken to identify potential GWAS SNPs, which associate with differential age of ACC onset. b–d Manhattan plot representing GWAS SNPs tested in BRZ1 (discovery) cohort with p-value represented in −log10(p) for each SNP (n = 61,609) (b). Manhattan plot representing the significant cancer GWAS SNPs (p < 0.05) in BRZ1 and their validation in the BRZ2 cohort (n = 2,644, out of 2,878 significant in BRZ1) (c). Manhattan plot representing the significant cancer GWAS SNPs in both BRZ1, BRZ2 and validated in the adult ACC cohort (n = 23, out of 34 significant in BRZ1 and BRZ2) (d). The significant SNP in the three cohorts is marked in red and pointed with an arrow.

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