Fig. 3: Differentiated tumour-infiltrating lymphocytes (TILs) densities according to HLA-I expression type and PD-L1 CPS status.

The distribution of TIL densities according to tumour location is shown here. a CD3⁺ TIL in the centre of tumour (CT), b CD3⁺ TIL in the invasive margin, c CD8⁺ TIL in the CT and d CD8⁺ TIL in the invasive margin (IM). In the CT, the density of CD3⁺ and CD8⁺ TIL was significantly lower in HLA-I total loss type of the PD-L1 combined positive score (CPS)-positive case (a, c). In the IM, the density of CD3⁺ and CD8⁺ TIL was significantly lower in HLA-I total loss type, independently of PD-L1 CPS positivity (b, d).