Fig. 5: Analysis of subtype-specific genetic properties by next-generation sequencing of OPC tumour DNA. | British Journal of Cancer

Fig. 5: Analysis of subtype-specific genetic properties by next-generation sequencing of OPC tumour DNA.

From: Molecular subtypes of oropharyngeal cancer show distinct immune microenvironment related with immune checkpoint blockade response

Fig. 5

a The oncomap showing genetic alterations of OPC tumours. The tumour-blood-matched targeted panel sequencing was performed in 13 out 37 OPC patients with available samples. The tumour subtype is indicated at the bottom of the map and the tumour mutation burden (TMB, non-synonymous mutations/Mb) was plotted. b The plot showing correlation between tumour mutation burden and TIDE score in OPC tumours. c Pie charts showing the proportion of COSMIC mutational signatures in XB type, MS type and IR type of OPC tumours. b The dot plot comparing the expression level of APOBEC family genes, APOBEC3B, APOBEC3D and APOBEC3G, in the three subtypes. The normalised expression level on RNA-seq was compared by unpaired t test. The expression values were compared using one-way ANOVA with Bonferroni post hoc test. The statistically significant results per post hoc analysis are indicated with asterisks (*p < 0.05).

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