Fig. 4: Ran regulates malignancy phenotypes in CRC cells through EGFR-dependent signalling. | British Journal of Cancer

Fig. 4: Ran regulates malignancy phenotypes in CRC cells through EGFR-dependent signalling.

From: Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells

Fig. 4

a Heatmap showing 38 genes with downregulated expression and 21 genes with upregulated expression at the mRNA level after Ran knockdown in HCT116 cells. The cut-off value was a twofold expression change, and the scale bar shows colour-coded differences in expression from the mean. b, c EGFR expression in SW480 and HT29 cells infected with LV-Ran or negative controls (b) and HCT116 and DLD-1 cells infected with LV-shRan or negative controls (c) was detected by qRT-PCR (*P < 0.05). d, e Western blot was used to detect the expression of ERK and AKT signalling pathway-related proteins in HT29 and SW480 cells infected with LV-Ran or negative controls (d) and HCT116 and DLD-1 cells infected with LV-shRan or negative controls (e).

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