Fig. 5: Functional characteristics of intratumoural CD103+CD8+ T cells in gastric cancer tissues. | British Journal of Cancer

Fig. 5: Functional characteristics of intratumoural CD103+CD8+ T cells in gastric cancer tissues.

From: Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis

Fig. 5

a Flow cytometry analysis of the proliferation marker Ki-67 in CD103-CD8+ and CD103+CD8+ T cells from gastric cancer tissues (n = 12). b Flow cytometry analysis of cytolytic markers (GZMB, CD107a and PRF1) in CD103-CD8+ and CD103+CD8+ T cells from gastric cancer tissues (n = 12). c Flow cytometry analysis of effector cytokines (IFN-γ, TNF-α and IL-2) in CD103-CD8+ and CD103+CD8+ T cells from gastric cancer tissues (n = 12). d Frequency of subsets with different combinations of IFN-γ, TNF-α and IL-2 in CD103-CD8+ and CD103+CD8+ T cells from gastric cancer tissues (n = 12) (left panel). Summary pie graphs representing the proportions of subsets with different combinations of IFN-γ, TNF-α and IL-2 in CD103-CD8+ and CD103+CD8+ T cells from gastric cancer tissues (right panel). e Flow cytometry analysis of coinhibitory receptors (PD-1, CTLA-4, TIM-3 and LAG-3) in CD103-CD8+ and CD103+CD8+ T cells from gastric cancer tissues (n = 12). GZMB granzyme B, IFN-γ interferon gamma, PRF1 perforin, IL-2 interleukin-2, PD-1 programmed cell death protein-1, CTLA-4 cytotoxic T lymphocyte-associated protein 4, TIM-3 T cell immunoglobulin domain and mucin domain 3, LAG-3 lymphocyte activation gene 3. Bar plots show the mean ± SD. Significance was assessed by paired t-test. n.s. not significant.

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