Table 3 Association between immune infiltrate and genetic alterations in HGSOC tumours.

From: Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma

 

BRCA1/BRCA2

p53 GOF/LOF

PTEN

CD8+

  Epithelium

0.04

0.54

0.67

  Stroma

0.17

0.29

0.07

  Average

0.17

0.53

0.84

CD45RO+

  Epithelium

0.20

0.42

0.92

  Stroma

0.46

0.84

0.82

  Average

0.10

0.36

0.87

CD68+

  Epithelium

0.43

0.72

0.79

  Stroma

0.78

0.85

0.65

  Average

0.68

0.66

0.41

Principal component

  1

0.81

0.80

0.55

  2

0.10

0.26

0.17

  3

0.27

0.58

0.51

  4

0.58

0.99

0.17

  5

0.76

0.88

0.79

  6

0.97

0.44

0.18

  1. P values were associated with Kruskal–Wallis test for detecting differences in mean ranks of immune infiltrate in patients grouped by mutation in BRCA1, BRCA2 or not-detected, p53 GOF or LOF and PTEN high or low in HGSOC.
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