Fig. 6: Risk of cancer over time by cancer stage.

Univariate smoothed hazard rate and cumulative hazard by cancer stage in patients with and without unexpected weight loss. In men, 54 cancers (0.2%) were diagnosed with late-stage cancer in 25,551 men with unexpected weight loss in the first 3 months rising to 66 (0.3%) cases over the first 6 months compared with 46 (0.04%) of 10,7706 men without unexpected weight loss in the first 3 months rising to 88 (0.08%) by 6 months. In women, 37 late-stage cancers (0.1%) were diagnosed in 36,057 women with unexpected weight loss in the first 3 months rising to 52 (0.1%) over 6 months compared with 38 (0.02%) in 145,203 women without unexpected weight loss over 3 months rising to 75 (0.05%) over 6 months.