Table 1 Characteristics of gastric cancer cases and controls in the PCCIU database and UK Biobank.
PCCIU | UK Biobank | |||
|---|---|---|---|---|
Cases, n (%) | Controls, n (%) | Gastric cancer, n (%) | No gastric cancer, n (%) | |
Count | 1119 (17.3) | 5394 (82.8) | 250 | 471,529 |
Median exposure years (Min, Max) | 5.1 (2.0, 13.7) | 5.1 (2.0, 13.7) | ||
Year of diagnosis | ||||
1996–1999 | 68 (6.1) | 332 (6.2) | ||
2000–2003 | 330 (29.5) | 1609 (29.8) | ||
2004–2007 | 494 (44.1) | 2359 (43.7) | 1 (0.4) | |
2008–2011 | 227 (20.3) | 1094 (20.3) | 99 (39.6) | |
2012–2015 | 150 (60.0) | |||
Age at index/baselinea | ||||
0–59 | 165 (14.8) | 818 (15.2) | 70 (28.0) | 273,444 (58.0) |
60–69 | 292 (26.1) | 1450 (26.9) | 175 (70.0) | 195,959 (41.6) |
70+ | 662 (59.2) | 3126 (57.9) | 5 (2.0) | 2126 (0.5) |
Male | 639 (57.1) | 3082 (57.1) | 182 (72.8) | 217,146 (46.1) |
Deprivation | ||||
1 (least deprived) | 133 (11.9) | 635 (11.9) | 41 (16.4) | 94,422 (20.0) |
2 | 182 (16.3) | 866 (16.0) | 40 (16.0) | 94,009 (19.9) |
3 | 242 (21.6) | 1167 (21.6) | 49 (19.6) | 93,929 (19.9) |
4 | 284 (25.4) | 1378 (25.5) | 55 (22.0) | 94,383 (20.0) |
5 (most deprived) | 268 (23.9) | 1300 (24.1) | 64 (25.6) | 94,194 (20.0) |
Missing | 10 (0.9) | 48 (0.9) | 1 (0.4) | 592 (0.1) |
Smoking statusb | ||||
Never | 387 (34.6) | 2052 (38.0) | 99 (39.6) | 257,994 (54.7) |
Former | 320 (28.6) | 1414 (26.2) | 106 (42.4) | 160,790 (34.1) |
Current | 249 (22.2) | 1009 (18.7) | 41 (16.4) | 50,005 (10.6) |
Missing | 163 (14.6) | 919 (17.0) | 4 (1.6) | 2740 (0.6) |
Selected comorbidities | ||||
GORD | 16 (6.4) | 19,582 (4.2) | ||
Peptic ulcer | 15 (1.3) | 75 (1.4) | 7 (2.8) | 5724 (1.2) |
Diabetes | 54 (4.8) | 222 (4.1) | 22 (8.8) | 23,821 (5.1) |
Oesophagitis | 7 (0.6) | 44 (0.8) | 4 (1.6) | 1361 (0.3) |
Other drug use | ||||
Statins | 265 (23.7) | 1248 (23.1) | 68 (27.2) | 76,473 (16.2) |
Aspirin | 358 (32.0) | 1610 (29.9) | 72 (28.8) | 64,717 (13.7) |
BMI | ||||
Normal/underweight | 61 (24.4) | 154,912 (32.9) | ||
Overweight | 119 (47.6) | 199,202 (42.2) | ||
Obese | 164 (14.7) | 1060 (19.7) | 70 (28.0) | 114,501 (24.3) |
Missing/not obese | 955 (85.3) | 4334 (80.4) | ||
Missing | 0 | 2914 (0.6) | ||
Alcohol consumption2 | ||||
Never | 237 (21.2) | 969 (18.0) | 27 (10.8) | 37,865 (8.0) |
<1 day per wk | 62 (24.8) | 106,482 (22.6) | ||
1–2 days per wk | 58 (23.2) | 121,461 (25.8) | ||
3–4 days per wk | 50 (20.0) | 108,892 (23.1) | ||
>4 days per wk | 51 (20.4) | 95,401 (20.2) | ||
Low | 529 (47.3) | 2660 (49.3) | ||
High | 42 (3.7) | 184 (3.4) | ||
Missing | 311 (27.8) | 1581 (29.3) | 2 (0.8) | 1428 (0.3) |
