Table 1 Demographic, clinical, and tumour characteristics of patients with hepatocellular carcinoma.
Patient demographics | Training cohort (nā=ā195) | Testing cohort (nā=ā114) | Validation cohort (nā=ā355) | P value |
---|---|---|---|---|
Age, years | ||||
Ā ā<60 | 150 | 88 | 263 | 0.68 |
Ā āā„60 | 45 | 26 | 92 | Ā |
Ā Sex (male), n (%) | 158 (81.0%) | 96 (84.2%) | 306 (86.2%) | 0.28 |
Ā HBV | 163 | 95 | 298 | 0.51 |
Ā Liver cirrhosis, yes (%) | 155 (79.5%) | 89 (78.1%) | 302 (85.1%) | 0.12 |
Ā AFP, ng/ml | 76.0 (6.0, 807.0) | 120.5 (5.3, 675.0) | 77.0 (5.0, 861.5) | 0.86 |
Ā Albumin, g/dl | 4.2 (3.9, 4.6) | 4.4 (4.1, 4.6) | 4.4 (4.0, 4.7) | 0.02 |
 Bilirubin, μmol/l | 15.1 (11.9, 19.0) | 15.0 (11.7, 19.4) | 14.1 (10.5, 18.4) | 0.05 |
Ā ALT, IU/l | 41.0 (27.5, 67.5) | 41.0 (27.5, 57.5) | 38.0 (26.0, 52.0) | 0.10 |
Ā GGT, U/l | 53.0 (34.0, 100.0) | 50.0 (30.3, 95.5) | 57.0 (37.0, 99.0) | 0.22 |
Ā Tumour diameter, cm | 4.0 (2.5, 6.0) | 4.0 (2.5, 7.0) | 3.5 (2.5, 6.0) | 0.41 |
Ā Microvascular invasion (yes), n (%) | 62 (31.8%) | 32 (28.1%) | 98 (27.6%) | 0.57 |
Tumour differentiation | ||||
Ā āIāII | 147 | 87 | 253 | 0.42 |
Ā āIIIāIV | 48 | 27 | 102 | Ā |
CGLC stage | Ā | Ā | Ā | 0.30 |
Ā āIa | 128 | 76 | 254 | Ā |
Ā āIb | 67 | 38 | 101 | Ā |
BCLC | ||||
Ā ā0 | 29 | 13 | 46 | 0.67 |
Ā āA | 166 | 101 | 309 | Ā |