Fig. 2: Tumour microenvironment heterogeneity underlying the variations in the MTR ratio. | British Journal of Cancer

Fig. 2: Tumour microenvironment heterogeneity underlying the variations in the MTR ratio.

From: Bimodal magnetic resonance and optical imaging of extracellular matrix remodelling by orthotopic ovarian tumours

Fig. 2

a MTR maps of the tumour area on days 6 and 13 after xenografting ES-2 cells (MRI in vivo). b Corresponding view of the same tumour within the anatomical context of the mouse abdomen post-mortem (stereomicroscopy ex vivo). Ovarian tumour with fluid-filled cyst encompassing the ovary, and part of the oviduct and uterine horn. c ES-2 cells imaged within de novo-forming collagen network in the mouse ovary (arrows) imaged throughout the imaging window with two-photon microscope 3 days post inoculation (Imaris rendering, MIP with 3D shading). The de novo-forming collagen fibres extend from the normal ovarian collagen. d The freshly excised tumour with reticuline network of collagen fibres, surrounding clusters of tumour cells. Cyan—tumour cells (eGFP), yellow—collagen (SHG).

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