Fig. 4: Endoscopic predictors of disease severity and clinical course.
From: Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Patients classified by the treatment required for the resolution of their colitis into three groups—steroid monotherapy <60 days, steroid monotherapy >60 days, or requirement for infliximab in addition to steroids. UCEIS and Mayo scores as assessed by two independent assessors (κ = 0.51, 0.54 respectively). a UCEIS score by treatment required for resolution (ANOVA: p = 0.008).30 b Mayo score by treatment required for resolution (ANOVA: p = 0.016).30 c The correlation between the presence of ulcers at endoscopy and the odds of eventually requiring infliximab (Fisher’s exact test: p = 0.01, odds ratio 7.6). The correlation between the serum CRP (d) (Least squares fit: 8.9; not significant) and serum albumin (e) (Least squares fit: 0.27; not significant) with the severity of inflammation as assessed by the UCEIS score. f Characteristic endoscopy appearances during irAE colitis and after resolution. UCEIS ulcerative colitis endoscopic index of severity score, CRP C-reactive protein, irAE immunotherapy-related adverse events.
