Table 3 Cox proportional hazard regression models for OS.
Characteristics | Univariate analysis HR (95% CI) | P | Multivariable model HR (95% CI) | P |
|---|---|---|---|---|
Age (years)a | 0.383 | – | ||
53 | Ref | – | ||
68 | 1.08 (0.91–1.29) | – | ||
Gender | 0.549 | – | ||
Female | Ref | |||
Male | 0.93 (0.73–1.19) | – | ||
ECOG PS | <0.001 | <0.001 | ||
0 | Ref | Ref | ||
1 | 1.96 (1.47–2.63) | 2.08 (1.53–2.85) | ||
Prior adjuvant treatment | 0.002 | 0.998 | ||
No | Ref | Ref | ||
Yes | 0.56 (0.38–0.81) | 1.00 (0.57–1.75) | ||
Primary tumour resected | 0.014 | 0.391 | ||
No | Ref | Ref | ||
Yes | 0.72 (0.56–0.94) | 0.88 (0.66–1.18) | ||
Liver-limited disease | 0.151 | – | ||
No | Ref | – | ||
Yes | 0.82 (0.63–1.07) | – | ||
Synchronous metastases | <0.001 | 0.043 | ||
No | Ref | Ref | ||
Yes | 1.87 (1.36–2.57) | 1.63 (1.02–2.61) | ||
Number of metastatic sites | 0.001 | 0.009 | ||
1 | Ref | Ref | ||
>1 | 1.51 (1.17–1.95) | 1.43(1.09–1.88) | ||
Primary tumour sidedness | 0.001 | 0.014 | ||
Left | Ref | Ref | ||
Right | 1.56 (1.20–2.03) | 1.42 (1.08–1.88) | ||
RAS/BRAF status | <0.001 | 0.003 | ||
RAS/BRAF wt | Ref | Ref | ||
RAS mut | 1.36 (1.06–1.74) | 1.29 (0.99–1.69) | ||
BRAF mut | 2.88 (1.72–4.84) | 2.65 (1.55–4.54) | ||
Study | 0.497 | – | ||
Valentino | Ref | – | ||
TRIBE | 0.91 (0.70–1.19) | – | ||
Backbone | 0.789 | – | ||
Doublet | Ref | – | ||
Triplet | 1.04 (0.80–1.34) | – | ||
NLR | <0.001 | 0.402 | ||
Low | Ref | Ref | ||
High | 1.56 (1.23–1.99) | 1.17 (0.81–1.68) | ||
PLT | <0.001 | 0.168 | ||
Low | Ref | Ref | ||
High | 1.67 (1.31–2.12) | 1.23 (0.92–1.64) | ||
MONO | 0.001 | 0.691 | ||
Low | Ref | Ref | ||
High | 1.52 (1.19–1.94) | 0.94 (0.70–1.27) | ||
SII | <0.001 | 0.677 | ||
Low | Ref | Ref | ||
High | 1.58 (1.24–2.01) | 0.91 (0.59–1.41) | ||
PIV | <0.001 | 0.042 | ||
Low | Ref | Ref | ||
High | 2.01 (1.57–2.57) | 1.55 (1.02–2.37) |
