Fig. 1: Decision curve analysis based on Gleason Grade.

The decision curve analysis compares the net benefit of the clinical + 4Kscore model (blue or dark grey dashed line), clinical-model (green or light grey dashed line), treat-all (orange or light grey solid line), and treat-none (horizontal red or grey solid line) strategies among biopsy (a) Gleason Grade 3 + 3 patients and (b) Gleason Grade 3 + 4 patients.