Table 2 Logistic regression analysis for the response to preoperative therapy (pCR).

From: Serial circulating tumour DNA analysis for locally advanced rectal cancer treated with preoperative therapy: prediction of pathological response and postoperative recurrence

Variables

Univariate analysis

Multivariate analysis

OR (95% CI)

P value

OR (95% CI)

P value

Gender: male vs female

1.7 (0.4–12)

0.5099

  

Pre-treatment CEA: < 5.0 ng/ml vs ≥5.0 ng/ml

1.1 (0.3–3.9)

0.9381

  

Distance from anal verge: ≥4 cm vs < 4 cm

2.0 (0.4–14)

0.4072

  

Clinical T factor: cT3 vs cT4

0.8 (0.2–4.1)

0.7441

  

Clinical N factor: negative vs positive

1.3 (0.3–5.0)

0.7353

  

NAC with CRT/SRT: yes vs no

2.9 (0.8–12.3)

0.1178

2.3 (0.6–10.4)

0.2396

aChange in ctDNA: ≥80% vs < 80%

8.5 (1.4–163)

0.0150

7.4 (1.2–144)

0.0276

  1. CEA carcinoembryonic antigen, ctDNA circulating tumour DNA, NAC neoadjuvant chemotherapy, CRT chemoradiotherapy, SRT short-course radiotherapy.
  2. aChange in ctDNA, 1—after/before the ratio of ctDNA (%).
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