Fig. 4: Radiotherapy causes temporal changes in the immune cell composition of TRAMP-C1 flank tumour allografts. | British Journal of Cancer

Fig. 4: Radiotherapy causes temporal changes in the immune cell composition of TRAMP-C1 flank tumour allografts.

From: Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model

Fig. 4

FACS analysis of the tumour immune microenvironment of TRAMP-C1 tumour allografts at the 7-day (a) and tumour regrowth to ≥400 mm3 (b) time-points post initiation of 3 × 5 Gy RT compared to untreated controls, with representative plots shown (c). Pie charts represent the proportion of CD45+ leucocytes within the total population of live cells. Quantification of PD-1 expression on gated CD45+CD8+ T-cells following treatment of TRAMP-C1 allograft tumours with 3 × 5 Gy RT compared to untreated controls (d). Data are presented as mean percentage of total live cells ± SEM and analysed by the unpaired t-test (n = at least 4 independent tumour samples analysed) *p < 0.05.

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