Table 1 Characteristics of the nine locoregional irradiations.

From: Concurrent use of palbociclib and radiation therapy: single-centre experience and review of the literature

Patient

Sites

CTVcc

PTVcc

Dose

Technique

Grade ≥ 2 acute toxicity

Palbociclib suspension due to toxicity

1

Left thoracic wall + left L1–L4 and IP

223

392

50 Gy (2 Gy/f)

Tomo

0

0

2

Right thoracic wall + right L2–L4, IP, and IMN

362

669

50 Gy (2 Gy/f)

VMAT

Neutropenia

0

3

Left breast + left L1–L4 and IP

566

820

50 Gy (2 Gy/f)

Tomo

0

0

4

Right breast + right L1–L4 and IP SIB

1082

1285

50.4 Gy (1.8 Gy/f) SIB: up to 64.4 Gy (2.3 Gy/f)

Tomo

0

0

5

Right thoracic wall + right L1–L4 and IP

395

725

50 Gy (2 Gy/f)

Tomo

0

0

6

Right thoracic wall + right L1–L4 and IP

511

805

50 Gy (2 Gy/f)

Tomo

0

0

7

Left thoracic wall + left L2–L4 and IP

533

778

50 Gy (2 Gy/f)

Tomo

0

0

8

Left breast + left L2–L4 and IP SIB

1355

1607

50.4 Gy (1.8 Gy/f) SIB: up to 64.4 Gy (2.3 Gy/f)

VMAT

Dermatitis, neutropenia and dysphagia

1

9

Bilateral thoracic walls +  bilateral L1–L4 and IP

1019

1607

50 Gy (2 Gy/f)

Tomo

Dermatitis, neutropenia and pain

1

  1. L1–L4 axillary level 1–3 and supraclavicular region (level 4), IP interpectoral (Rotter) nodes, IMN internal mammary nodes, SIB simultaneous integrated boost, 2Gy/f 2 Gy per fraction, Tomo tomotherapy, VMAT volumetric modulated arc therapy.