Fig. 5: M2BPGi enhances mTOR signaling in HCC cells in the presence of galectin-3 (Gal-3). | British Journal of Cancer

Fig. 5: M2BPGi enhances mTOR signaling in HCC cells in the presence of galectin-3 (Gal-3).

From: Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling

Fig. 5

a Enhanced mTOR signaling in M2BPGi-treated PLC/PRF/5 cells by GO analyses. b M2BPGi induced the phosphorylation of mTOR, p70–S6K and S6 in PLC/PRF/5 cells. c Phospho-S6 was enhanced in the lysates of M2BPGi-treated xenograft tumour tissues. Representative images of phospho-S6 staining (×400 magnification). d Gal-3 downregulation reduced the expression of mTOR -signaling pathway. e The proliferative effects of M2BPGi on HCC cells were inhibited by treatment with rapamycin (mTOR inhibitor) (n = 6, *p < 0.01). f Schema of the mTOR-meditated functions of M2BPGi.

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