Fig. 5: Overall survival for algorithms of TP53 mutational status.

Multivariate survival analysis of patients with head and neck squamous cell carcinoma, showing differences among patients with disruptive (yellow line) and conservative (green line) mutations in TP53 gene according to Poeta's classification (a); and patients with high risk (yellow line) and low risk (green line) death mutations, according to our new classification system (b). Blue lines are, in both of cases, representative of wild-type (WT) patients.