Table 4 PK assessment with all LY3127804 doses at different administration times.
LY dose (mg/kg) | Day | N | Cmax (ng/mL) | AUC(0-336) (µg·h/mL) | AUC(0-∞) (µg·h/mL) | CL (mL/h) | t1/2 (h) |
|---|---|---|---|---|---|---|---|
4 | 1 | 3 | 96,867 (57) | 11,631 (30) | 16,737 (34) | 16.5 (28) | 199 (16) |
15 | 3 | 100,120 (22) | 16,647 (33) | – | 16.8 (25) | 202 (21) | |
29 | 3/2a | 109,960 (27) | 16,136 (27)a | – | 15.3 (31)a | 211 (27)a | |
43 | 2 | 96,380 (26) | – | – | – | – | |
8 | 1 | 9/6a | 187,210 (20) | 29,817 (25)a | 44,854 (31) | 15.3 (13)a | 202 (21)a |
15 | 9 | 225,140 (28) | 42,486 (22) | – | 14.4 (22) | 240 (36) | |
29 | 6/5a | 310,580 (36) | 53,889 (41)a | – | 12.2 (40)a | 211 (55)a | |
43 | 9 | 303,320 (21) | – | – | – | – | |
12 | 1 | 9 | 231,190 (29) | 33,036 (31) | 50,661 (40) | 18.5 (43) | 220 (33) |
15 | 8/6a | 294,290 (32) | 47,084 (35) | – | 20.3 (42) | 199 (25)a | |
29 | 9/8a | 342,140 (24) | 62,327 (26) | – | 15.5 (35) | 209 (24)a | |
43 | 8 | 390,170 (13) | – | – | – | – | |
16 | 1 | 9 | 313,230 (22) | 43,636 (25) | 73,477 (46) | 15.5 (38) | 255 (41) |
15 | 10 | 347,080 (39) | 65,837 (39) | – | 16.8 (24) | 270 (26) | |
29 | 8/5a | 480,120 (23) | 93,032 (25) | – | 13.0 (26) | 248 (7.1)a | |
43 | 9 | 439,330 (22) | – | – | – | – | |
20 | 1 | 17 | 423,120 (35) | 57,917 (23) | 91,311 (32) | 15.8 (33) | 228 (50) |
15 | 13 | 531,190 (17) | 85,529 (22) | – | 16.9 (25) | 227 (25) | |
29 | 14/10a | 631,940 (27) | 106,655 (28) | – | 13.4 (25) | 238 (38)a | |
43 | 10 | 620,870 (16) | – | – | – | – | |
27 | 1 | 12 | 551,370 (36) | 81,931 (28) | 122,518 (34) | 16.6 (38) | 211 (39) |
15 | 9 | 608,330 (38) | 108,015 (24) | – | 18.2 (21) | 202 (42) | |
29 | 10/8a | 721,420 (30) | 120,607 (29)a | – | 15.9 (23)a | 185 (19)a | |
43 | 8 | 797,710 (19) | – | – | – | – |
