Table 1 Univariate and multivariate analyses for overall survival (OS).

From: Integrated clinico-molecular profiling of appendiceal adenocarcinoma reveals a unique grade-driven entity distinct from colorectal cancer

Variables

Category

Univariate analysis

Multivariate analysisa

OS (months) (95%CI)

HR (95%CI)

P value

HR (IC 95%)

P value

Age (years)

>60

47.0 (30.0, 63.9)

1.25 (0.7–2.1)

0.399

  

≤60

76.6 (58.1, 95.0)

Gradeb

1

137.8 (52.7, 223.0)

Ref.

Ref.

Ref.

 

2

75.8 (58.1, 93.4)

6.09 (2.2–16.7)

<0.001

5.7 (2.0–16.3)

0.001

3

41.9 (27.3, 56.6)

11.6 (4.3–31.5)

<0.001

9.7 (3.3–28.8)

<0.001

CRS + HIPEC

Yes

120.0 (59.5–180.6)

0.35 (0.2–0.6)

<0.001

0.44 (0.3–0.7)

0.002

No

40.3 (28.5–52.2)

Chemotherapy

Yes

75.8 (55.6, 96.0)

1.47 (0.8–2.8)

0.242

  

No

Not reached

RAS

Mutant

75.8 (44.8, 106.7)

0.94 (0.6–1.5)

0.792

  

Wild-type

76.2 (50.0, 102.4)

GNAS

Mutant

Not reached

0.53 (0.3–0.9)

0.026

1.07 (0.5–2.2)

0.845

Wild-type

61.0 (35.0, 87.1)

TP53

Mutant

31.8 (16.4, 47.2)

2.06 (1.3–3.3)

0.002

1.38 (0.8–2.5)

0.278

Wild-type

76.9 (59.4, 94.3)

SMAD4

Mutant

74.0 (15.0, 133.0)

1.30 (0.8–2.3)

0.284

  

Wild-type

76.6 (42.3, 110.8)

  1. CI confidence interval, OS overall survival, Ref. reference.
  2. aMultivariate analysis performed using factors significant in univariate analysis.
  3. bGrades 1, 2 and 3 imply well, moderately and poorly differentiated tumour, respectively.
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